Hydroxychloroquine retinopathy, also known as Plaquenil toxicity, is a serious eye condition that can occur with long-term use of Plaquenil. Understanding the causes, risks, and early symptoms is essential for protecting your vision.
What is Hydroxychloroquine Retinopathy?
This condition occurs when hydroxychloroquine accumulates in the retina, causing damage to the macula and retinal pigment epithelium. Damage is often irreversible if not detected early.
How Hydroxychloroquine Affects the Eyes
- Disrupts retinal cell function
- Can lead to thinning of retinal layers detectable on OCT scans
- May cause central vision loss or blind spots over time
Risk Factors for Retinopathy
- Long-term use (usually over 5 years)
- High cumulative doses
- Kidney or liver disease affecting drug metabolism
- Pre-existing retinal disease
Symptoms to Watch For
- Blurred or distorted central vision
- Trouble seeing in low light
- Changes in color perception
- Ring-shaped blind spots or central scotomas
For more detailed symptom information, visit our Symptoms and Side Effects page.
Preventive Measures and Early Detection
- Baseline eye exam within the first year of starting Plaquenil
- Annual screenings after five years, or sooner for high-risk patients
- Report any vision changes immediately
For common questions about monitoring and testing, see our Common Questions page.
